The National Lung Cancer Audit: The Impact of COVID-19.

Since 2014, the National Lung Cancer Audit (NLCA) has been evaluating the performance of the UK NHS lung cancer services against established standards of care. Prior to the onset of the COVID-19 pandemic, the NLCA's annual reports revealed a steady stream of improvements in early diagnosis, access to surgery, treatment with anti-cancer therapies, input from specialist nursing and survival for patients with lung cancer in the NHS. In January 2022, the NLCA reported on the negative impact COVID-19 has had on all aspects of the lung cancer diagnosis and treatment pathway within the NHS. This article details the fundamental changes made to the NLCA data collection and analysis process during the COVID-19 pandemic and details the negative impact COVID-19 had on NHS lung cancer patient outcomes during 2020.

169 Improving the care of lung cancer patients of borderline fitness for surgery: a case study by the Accelerate, Coordinate and Evaluate Programme (ACE) programme

Background: There is wide variation in resection and other radical treatment rates for lung cancer patients in the UK. Many patients pose complex problems around staging and assessment of fitness for radical treatment, one such group being those patients deemed ‘borderline fit' for surgery. Cancer Research UK's ACE Programme is exploring how fitness is assessed in such patients across the UK, the extent to which prehabilitation is available and used and how other radical treatment options, especially Stereotactic Body Radiotherapy (SBRT), are considered. Methodology: In collaboration with the Society of Cardiothoracic Surgeons, a questionnaire was sent to trusts in November 2020 that specialise in thoracic surgery, focusing on: their access to, and management of, a prehabilitation programme;methods used to assess fitness for surgery;access to a clinical oncologist with expertise in SBRT Results: To date, a total of 20/32 units responded. Findings include: 15/20 offer a prehabilitation programme mostly available within 2 weeks. The programmes typically last 1-2 weeks. 10 respondents are running virtual sessions due to COVID-19;standard pulmonary function tests are available to all units and 17/20 units have access to cardiopulmonary exercise testing and echocardiogram;complex case MDTs are run by 14/20 units, 13 including attendance from anaesthetists;an oncologist with SBRT expertise is available to all MDTs;a 2nd opinion is obtained in 17/20 units, of these 9/17 were following patient request Conclusion: It is encouraging to see wider application of prehabilitation programmes for borderline fitness patients in the UK. Such enhanced management of these patients could reduce variation in treatment rates and improve outcomes. The ACE Programme plans to use this preliminary work to develop examples of best practice and support implementation to achieve these aims. Disclosure: No significant relationships.

Emerging Wake-up Call before next Pandemics as Apart of Medicine and Technology: We terribly need Social and Healthcare Workers

Thousands of healthcare and social workers (HCSW) died or lost their ability to work in their field after Covid pandemics in all three waves, and thousands left their profession due to burnout syndrome. Despite development of vaccines took 6-18 months and refreshment of old molecules for treatment weeks, many countries paid a very high price for this pan-demics not due to lack of medications or ventilator assistance devices but due to the increasing lack of trained HCSW.

Implementation of a successful convalescent plasma program

Background/Case Studies: On March 11, 2020, the WHO declared SARS-CoV-2 a global pandemic. In late March 2020, the FDA issued the first guidance on use of convalescent plasma (CCP) for patients with COVID-19 under investigational use. After the initiation of the expanded access protocol in April 2020, the authors' community-based blood center quickly created a program to identify CCP donors and ensure continuing donation. Study Design/Methods: The Contact Center created an online form for inquiries about donating CCP. A special team evaluated incoming requests and determined if a donor was eligible for antibody testing and then donation if positive for antibodies. The Public Relations (PR) team used numerous channels for messaging about CCP donations: social media, digital ads, mail, email and text. PR and the Executive team created a partnership with the governor's office, public health department, and state testing lab. Initially, only potential CCP donors were tested for antibodies using the state lab. Starting August 3, 2020, all donations were tested for antibodies if consent was received. Testing was done in partnership with a state university and the state lab;in November the state lab became the sole tester. Non-CCP donors that qualified were recruited to CCP donation, and if the donation that tested positive had an acceptable plasma product, it was converted to CCP. The blood center has three apheresis devices, one of which was switched to CCP collection only. High titer CCP was implemented on February 10, 2021, in response to the updated FDA EUA and anticipated requests for high titer only from hospitals. The state lab provided titer levels going back to early December 2020;current CCP inventory was relabeled if high titer. Results/Findings: Total average collection volume was 770 mL, which resulted in 3 to 4 units of CCP per donation. The total number of CCP donors was 3,734;643 were first-time donors. Units collected, including whole blood plasma converted to CCP, totaled 23,791. Of the collected units, 17,304 were shared regionally and nationally, and 2,254 were sent to national stockpiles. Of all donors tested for antibodies, 27% tested positive;CCP donors had an 88% positivity rate. After the switch to high titer, 26% of all donors were positive, and 60% of CCP donors were positive. Conclusions: Implementing a successful CCP program took every department of the blood center: PR recruited potential donors, the Contact Center evaluated donors for eligibility and scheduled donations, Donor Services utilized all their devices to collect CCP as well as continued collection of normal blood donations, Hospital Services created and shipped CCP and handled COVID antibody testing, and IT set up the computer system for the new donation code and testing. Thus, the blood center was able to consistently meet the CCP demands of local hospitals, other blood centers, and the national stockpile.

SELECTED RELEVANT NEGATIVE CONSEQUENCES OF COVID-19 PANDEMIC FOR MARRIAGE AND PARTNERSHIP AND SUGGESTED EFFICIENT SOLUTIONS

Background: This contribution stems from specialised research results carried out by means of specific case studies on the basis of qualitative research by using online interviews to map the consequences of coronavirus SARS-CoV-2 (COVID-19) pandemic and its impact on married couples and cohabitating partners. This research was conducted from late March until mid-October 2020.Three hundred married couples and partners from various countries participated in the research. Conclusion: Research results can be applied in further analyses as a basis for relevant and beneficial research which can also be expanded in the period of long-term negative consequences of COVID-19 or during similar pandemics and their negative consequences on married couples and partners.